![]() Bioinformatics 21:3596–3603Īltschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. Key pointsĪllen JE, Salzberg SL (2005) JIGSAW: integration of multiple sources of evidence for gene prediction. The intent of this article is to compile a list of tools and information resources used by scientists to treat information from the massive sequencing of recent platforms to new generations and the applications of this information in different areas of life sciences including medicine. Recently, sequencing platforms, a large scale of genomes and transcriptomes, have created new challenges not only to the genomics but especially for bioinformatics. The goal is to provide scientists with the right means to explain normal biological processes, dysfunctions of these processes which give rise to disease and approaches that allow the discovery of new medical cures. All this work produces an “ocean” of information that can only be “sailed” with the help of computerized methods. Bioinformatics combines the methods used in the collection, storage, identification, analysis, and correlation of this huge and complex information. Overall, the Serial Cloner app provides you with a useful set of tools for DNA cloning and sequence visualization.While we have a basic understanding of the functioning of the gene when coding sequences of specific proteins, we feel the lack of information on the role that DNA has on specific diseases or functions of thousands of proteins that are produced. By default the Help window is permanently displayed and provides you with tips for the window or field hovered by the mouse cursor. The interface is intuitive and provides quick access to all the important features.Īlthough the program is clearly designed for users accustomed with molecular biology analysis, it features an extensive documentation that helps beginners get used to the features. This enables you to work with sequences created by other laboratories in order to compare the results.ĭuring our tests Serial Cloner required insignificant resources and had no impact on the other applications even when generating complex graphical maps. The application allows you to import the data from multiple programs and supports various file formats such as Vector NTI, MacVector, ApE, DNAstar, pDRAW32 and GenBank. ![]() You can also export the collection of features, align protein sequences and reverse translate proteins with minimum effort. If the analysis results are required in another document you can simply copy-paste the map or save it as an image on your hard drive. The graphical map supports further formatting which enables you to specify the displayed elements. The program can help you find restriction sites and build a text restriction map which enables you to add multi-frame translations. It is designed to handle all the data in a single interface which makes it easy to use when manipulating sequences. You can use this tool for analyzing the datasets, selecting certain fragments and calculate Tm values with just a few clicks. ![]() It deals with the analysis and visualization of sequences in the field of molecular biology. ![]() Serial Cloner is a powerful tool for the laboratory staff and the students who work with nucleotide and peptide sequences.
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